一、lose at (v.+prep.) 在…(比賽)中失敗 fail to win at (game)。
基本句型： lose at sth：
例：I always lose at cards， with my bad luck.
我不走運，打牌總輸。
二、lose by (v.+prep.)因…蒙受損失;因…失去。
基本句型：
1、lose by sth.
例：Put your money into our savings plan， and you can't lose by it.
按我們的儲蓄計劃把錢存起來，你就不會蒙受什麼損失。
2、lose sth by sth.
例：The government may lose seats by the reorganization of voting areas.
政府可能會因為調整選區而失去席位。
三、lose in (v.+prep.)(指某種聲音)被(其他聲音)淹沒，吞沒。
基本句型：
1、lose sth/oneself in sth.
例：We lost ourselves in the dark.
我們在黑暗中迷路。
2、lose oneself in sth.
例：I can always lose myself in a good book.
一本好書會使我愛不釋手。